Wnt/β-Catenin-Activated Nonpilomatrical Carcinoma of the Skin: A Case Series.

doi:10.1016/j.modpat.2024.100586

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Article

Wnt/β-Catenin-Activated Nonpilomatrical Carcinoma of the Skin: A Case Series.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2024

Kervarrec Thibault, Cheok Lei Kuan, Sohier Pierre, Macagno Nicolas, Jullie Marie-Laure, Frouin Eric, Goto Keisuke, Taniguchi Kohei, Hamard Aymeric, Taillandier Antoine, Tallet Anne, Bonenfant Christine, Sahin Yusuf, Barry Fatoumata, Taibjee Saleem, Cokelaere Kristof, Houben Roland, Schrama David, Nardin Charlee, Aubin Francois, Doucet Laurent, Pissaloux Daniel, Tirode Franck, Fouchardière Arnaud de la, Balme Brigitte, Laurent-Roussel Sara, Becker Jürgen C, von Deimling Andreas, Samimi Mahtab, Cribier Bernard, Battistella Maxime, Calonje Eduardo, Guyétan Serge

Abstract excerpt

Among skin epithelial tumors, recurrent mutations in the APC/CTNNB1 genes resulting in activation of the Wnt/β-catenin pathway have been reported predominantly in neoplasms with matrical differentiation. In the present study, we describe the morphologic, immunohistochemical, and genetic features of 16 primary cutaneous carcinomas harboring mutations activating the Wnt/β-catenin pathway without evidence of...

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Identifiers

PMID: 39094735
DOI: 10.1016/j.modpat.2024.100586

Genes

APC
CTNNB1
MCC
CDX2
RB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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