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Article

Nonlinear causal effects of estimated glomerular filtration rate on myocardial infarction risks: Mendelian randomization study.

BMC medicine - 3 Feb 2022

Park Sehoon, Lee Soojin, Kim Yaerim, Cho Semin, Huh Hyeok, Kim Kwangsoo, Kim Yong Chul, Han Seung Seok, Lee Hajeong, Lee Jung Pyo, Joo Kwon Wook, Lim Chun Soo, Kim Yon Su, Kim Dong Ki

Abstract excerpt

BACKGROUND: Previous observational studies suggested that a reduction in estimated glomerular filtration rate (eGFR) or a supranormal eGFR value was associated with adverse cardiovascular risks. However, a previous Mendelian randomization (MR) study under the linearity assumption reported null causal effects from eGFR on myocardial infarction (MI) risks. Further investigation of the nonlinear causal effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35109828
DOI: 10.1186/s12916-022-02251-1
PMCID: PMC8811984

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