Article

Vasculopathy in Sickle Cell Disease: From Red Blood Cell Sickling to Vascular Dysfunction

2021-04-01

Abstract excerpt

Abstract Sickle cell disease (SCD) is a hereditary disorder that leads to the production of an abnormal hemoglobin, hemoglobin S (HbS). HbS polymerizes in deoxygenated conditions, which can prompt red blood cell (RBC) sickling and leaves the RBCs more rigid, fragile, and prone to hemolysis. SCD patients suffer from a plethora of complications, ranging from acute complications, such as characteristic, frequent, and...

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Literature Corpus work: f6c47f45-51cb-5506-b028-7f45e192b119
DOI: 10.1002/j.2040-4603.2021.tb00164.x

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