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Article

Markers of endothelial dysfunction differ between subphenotypes in children with sickle cell disease.

Thrombosis research - 1 Jan 2013

van der Land Veronica, Peters Marjolein, Biemond Bart J, Heijboer Harriët, Harteveld Cornelis L, Fijnvandraat Karin

Abstract excerpt

In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfunction subphenotype (HED) suffer from stroke and pulmonary hypertension and have an elevated...

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Source

Identifiers

PMID: 24182550
DOI: 10.1016/j.thromres.2013.10.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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