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Article

Vasculature and Kidney Complications in Sickle Cell Disease

24 Mar 2012

Abstract excerpt

Recent developments in sickle cell disease include the concept of a vasculopathic state and the classification of sickle cell disease into a hemolysis-endothelial dysfunction phenotype or a viscosity-vasoocclusion phenotype. The hemolysis-endothelial dysfunction phenotype largely reflects deficiency of or resistance to nitric oxide. In addition to discussing these areas, we suggest that the hemolysis-endothelial...

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PMID: 22440903
DOI: 10.1681/asn.2011101019

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