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Article

Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Apr 2011

Wu Ming-Fung, Nienhuis Robert, Maidment Nigel, Lam Hoa A, Siegel Jerome M

Abstract excerpt

Hypocretin receptor-2 (Hcrt-r2)-mutated dogs exhibit all the major symptoms of human narcolepsy and respond to drugs that increase or decrease cataplexy as do narcoleptic humans; yet, unlike narcoleptic humans, the narcoleptic dogs have normal hypocretin levels. We find that drugs that reduce or increase cataplexy in the narcoleptic dogs, greatly increase and decrease, respectively, hypocretin levels in normal...

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Identifiers

PMID: 21525270
DOI: 10.1523/JNEUROSCI.0365-11.2011
PMCID: PMC3097029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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