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Article

Cryo-EM structures and functional characterization of homo- and heteropolymers of human ferritin variants.

Scientific reports - 26 Nov 2020

Irimia-Dominguez Jose, Sun Chen, Li Kunpeng, Muhoberac Barry B, Hallinan Grace I, Garringer Holly J, Ghetti Bernardino, Jiang Wen, Vidal Ruben

Abstract excerpt

The role of abnormal brain iron metabolism in neurodegenerative diseases is still insufficiently understood. Here, we investigate the molecular basis of the neurodegenerative disease hereditary ferritinopathy (HF), in which dysregulation of brain iron homeostasis is the primary cause of neurodegeneration. We mutagenized ferritin's three-fold pores (3FPs), i.e. the main entry route for iron, to investigate...

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Identifiers

PMID: 33244127
DOI: 10.1038/s41598-020-77717-4
PMCID: PMC7692541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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