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Article

Iron loading-induced aggregation and reduction of iron incorporation in heteropolymeric ferritin containing a mutant light chain that causes neurodegeneration.

Biochimica et biophysica acta - 1 Apr 2011

Muhoberac Barry B, Baraibar Martin A, Vidal Ruben

Abstract excerpt

Hereditary ferritinopathy (HF) is a neurodegenerative disease characterized by intracellular ferritin inclusion bodies (IBs) and iron accumulation throughout the central nervous system. Ferritin IBs are composed of mutant ferritin light chain as well as wild-type light (Wt-FTL) and heavy chain (F...

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Source

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Identifiers

PMID: 21029774
DOI: 10.1016/j.bbadis.2010.10.010
PMCID: PMC3040265

Genes

FTL
FTH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21029774-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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