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Article

Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration.

The Journal of biological chemistry - 14 Nov 2008

Baraibar Martin A, Barbeito Ana G, Muhoberac Barry B, Vidal Ruben

Abstract excerpt

Nucleotide insertions in the ferritin light chain (FTL) polypeptide gene cause hereditary ferritinopathy, a neurodegenerative disease characterized by abnormal accumulation of ferritin and iron in the central nervous system. Here we describe for the first time the protein structure and iron storage function of the FTL mutant p.Phe167SerfsX26 (MT-FTL), which has a C terminus altered in sequence and extended in...

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Identifiers

PMID: 18755684
DOI: 10.1074/jbc.M805532200
PMCID: PMC2581579

Genes

FTL

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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