Structural Analysis of Variants of the Ferritin Light Chain Protein and Its Relationship with Neuroferritinopathy.

Abstract excerpt

Ferritin is a highly conserved spherical protein that stores iron and possesses triple and quadruple symmetry input ports. Additionally, it is composed of light chains that can be affected by post-translational mutations, reducing the iron storage capacity in the brain and leading to neuroferritinopathy, which is a rare disease with limited bioinformatics data. In this study, we analyzed the biochemical mechanism...

Topics

• Apoferritins
• Humans
• Neuroaxonal Dystrophies
• Iron Metabolism Disorders
• Mutation
• Protein Conformation
• Models, Molecular