Article

IntAct: a non-disruptive internal tagging strategy to study actin isoform organization and function

2021-10-28

Abstract excerpt

Actin plays a central role in many cell biological processes including division and motility. Mammals have six, highly conserved actin isoforms with nonredundant biological functions, yet the molecular basis of isoform specificity remains elusive due to a lack of tools. Here, we describe the development of IntAct, an internal tagging strategy to study actin isoform function in fixed and living cells. We first iden...

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Literature Corpus work: fe1b7fd4-9053-5e2c-9235-1efd575aab0e
DOI: 10.1101/2021.10.25.465733

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