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Article

Evaluating the frequency and the impact of pharmacogenetic alleles in an ancestrally diverse Biobank population.

Journal of translational medicine - 28 Nov 2022

Verma Shefali S, Keat Karl, Li Binglan, Hoffecker Glenda, Risman Marjorie, Sangkuhl Katrin, Whirl-Carrillo Michelle, Dudek Scott, Verma Anurag, Klein Teri E, Ritchie Marylyn D, Tuteja Sony

Abstract excerpt

BACKGROUND: Pharmacogenomics (PGx) aims to utilize a patient's genetic data to enable safer and more effective prescribing of medications. The Clinical Pharmacogenetics Implementation Consortium (CPIC) provides guidelines with strong evidence for 24 genes that affect 72 medications. Despite strong evidence linking PGx alleles to drug response, there is a large gap in the implementation and return of actionable...

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Identifiers

PMID: 36443877
DOI: 10.1186/s12967-022-03745-5
PMCID: PMC9703665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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