Article
Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network.
Clinical pharmacology and therapeutics - 1 Aug 2016
Bush W S, Crosslin D R, Owusu-Obeng A, Wallace J, Almoguera B, Basford M A, Bielinski S J, Carrell D S, Connolly J J, Crawford D, Doheny K F, Gallego C J, Gordon A S, Keating B, Kirby J, Kitchner T, Manzi S, Mejia A R, Pan V, Perry C L, Peterson J F, Prows C A, Ralston J, Scott S A, Scrol A, Smith M, Stallings S C, Veldhuizen T, Wolf W, Volpi S, Wiley K, Li R, Manolio T, Bottinger E, Brilliant M H, Carey D, Chisholm R L, Chute C G, Haines J L, Hakonarson H, Harley J B, Holm I A, Kullo I J, Jarvik G P, Larson E B, McCarty C A, Williams M S, Denny J C, Rasmussen-Torvik L J, Roden D M, Ritchie M D
Abstract excerpt
Genetic variation can affect drug response in multiple ways, although it remains unclear how rare genetic variants affect drug response. The electronic Medical Records and Genomics (eMERGE) Network, collaborating with the Pharmacogenomics Research Network, began eMERGE-PGx, a targeted sequencing study to assess genetic variation in 82 pharmacogenes critical for implementation of "precision medicine." The February...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.