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Article

Deep Learning of Sequence Patterns for CCCTC-Binding Factor-Mediated Chromatin Loop Formation.

Journal of computational biology : a journal of computational molecular cell biology - 1 Feb 2021

Kuang Shuzhen, Wang Liangjiang

Abstract excerpt

The three-dimensional (3D) organization of the human genome is of crucial importance for gene regulation, and the CCCTC-binding factor (CTCF) plays an important role in chromatin interactions. However, it is still unclear what sequence patterns in addition to CTCF motif pairs determine chromatin loop formation. To discover the underlying sequence patterns, we have developed a deep learning model, called...

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PMID: 33232622
DOI: 10.1089/cmb.2020.0225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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