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Article

Immunoglobulin G of systemic sclerosis patients programs a pro-inflammatory and profibrotic phenotype in monocyte-like THP-1 cells.

Rheumatology (Oxford, England) - 18 Jun 2021

Murthy Sripriya, Wannick Melanie, Eleftheriadis Georgios, Müller Antje, Luo Jiao, Busch Hauke, Dalmann Anja, Riemekasten Gabriela, Sadik Christian D

Abstract excerpt

OBJECTIVES: Functional IgG autoantibodies against diverse G protein-coupled receptors, i.e. antibodies with agonistic or antagonistic activity at these receptors, are abundant in human serum. Their levels are altered in patients with SSc, and autoantibodies against angiotensin II receptor 1 (ATR1) and endothelin receptor A (ETA) have been suggested to drive SSc by inducing the chemokines CXCL8 and CCL18 in the...

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PMID: 33230552
DOI: 10.1093/rheumatology/keaa747

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