Article
The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.
PloS one - 17 Jun 2009
Radstake Timothy R D J, van Bon Lenny, Broen Jasper, Hussiani Anila, Hesselstrand Roger, Wuttge Dirk M, Deng Yanhui, Simms Robbert, Lubberts Erik, Lafyatis Robert
Abstract excerpt
BACKGROUND: Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. METHODOLOGY AND PRINCIPAL FINDINGS: Patients were subdivided as having limited cutaneous SSc (lcSSc, n = 12) or diffuse cutaneous SSc (dcSSc, n = 24). A further arbitrary subdivision was made between early dcSSc (n = 11) and...
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