Update on pathophysiology of scleroderma with special reference to immunoinflammatory events

Abstract excerpt

Scleroderma or systemic sclerosis (SSc) is a complex disease in which the vasculopathy and the activation of the immune system with production of inflammatory mediators lead to dysregulated fibroblast activation. The resulting excessive deposition of collagens and other extracellular matrix proteins ends in fibrosis and organ dysfunction. The cause is unknown, but environmental factors are thought to play a role...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Connective Tissue Growth Factor Research
• Share to Dermatologic Treatments and Research
• Share to Systemic Sclerosis and Related Diseases