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Article

Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h.

Nature cell biology - 1 Dec 2020

Espanola Sophia G, Song Hyemin, Ryu Eunjin, Saxena Aditya, Kim Eun-Sun, Manegold Jennifer E, Nasamran Chanond A, Sahoo Debashis, Oh Chang-Kyu, Bickers Cara, Shin Unbeom, Grainger Stephanie, Park Yong Hwan, Pandolfo Lauren, Kang Mi-Sun, Kang Sukhyun, Myung Kyungjae, Cooper Kimberly L, Yelon Deborah, Traver David, Lee Yoonsung

Abstract excerpt

Haematopoietic stem and progenitor cells (HSPCs) have been the focus of developmental and regenerative studies, yet our understanding of the signalling events regulating their specification remains incomplete. We demonstrate that supt16h, a component of the Facilitates chromatin transcription (FACT) complex, is required for HSPC formation. Zebrafish supt16h mutants express reduced levels of Notch-signalling...

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Identifiers

PMID: 33230303
DOI: 10.1038/s41556-020-00604-7
PMCID: PMC8092813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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