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Article

Regulatory Single Nucleotide Polymorphism Increases TERT Promoter Activity in Thyroid Carcinoma Cells.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2020

Hirokawa Tatsuya, Arimasu Yuu, Chiba Tomohiro, Nakazato Yoko, Fujiwara Masachika, Kamma Hiroshi

Abstract excerpt

BACKGROUND/AIM: The telomerase reverse transcriptase (TERT) promoter has a regulatory single nucleotide polymorphism (rSNP), rs2853669, and occasionally shows point mutations C228T and C250T. Although C228T and C250T have been well examined to increase TERT promoter activity and are known as risk factors for thyroid carcinoma, the significance of rs2853669 has not been well investigated. This study aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic
Share to Mutation
Share to Polymorphism, Single Nucleotide
Share to Promoter Regions, Genetic
Share to Telomerase
Share to Thyroid Neoplasms

Source

Identifiers

PMID: 33227798
DOI: 10.1159/000509752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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