Article
Genetics variants and expression of the SCARB2 gene in the pathogenesis of Parkinson's disease in Russia.
Neuroscience letters - 10 Jan 2021
Usenko T S, Bezrukova A I, Bogdanova D A, Kopytova A E, Senkevich K A, Gracheva E V, Timofeeva A A, Miliukhina I V, Zakharova E Y, Emelyanov A K, Pchelina S N
Abstract excerpt
Lysosomal integral membrane protein-2 (LIMP-2), encoded by the SCARB2 gene, is the specific lysosomal receptor for glucocerebrosidase enzyme. Association between rs6812193 and rs68250047 of SCARB2 with PD has been shown in genetic studies, including large genome-wide association studies. The aim of the current study was to determine whether rs6812193 and rs8475 are associated with PD in Russia. rs6812193 and...