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Article

RNA structure and packaging signals in the 5' leader region of the human immunodeficiency virus type 1 genome.

Journal of virology - 1 Dec 2002

Clever Jared L, Miranda Daniel, Parslow Tristram G

Abstract excerpt

The leader region of the human immunodeficiency virus type 1 (HIV-1) genome has a highly folded structure, comprising at least two RNA stem-loops [the transactivation response (TAR) and poly(A) hairpins] near its 5' end and four others (SL1 to SL4) downstream. Each of these stem-loops contributes to the function of the HIV-1 packaging signal, which efficiently targets genomic RNA into nascent virions. The central...

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Identifiers

PMID: 12414982
DOI: 10.1128/jvi.76.23.12381-12387.2002
PMCID: PMC136901

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Source receipt: pubmed, retrieved 7 Sept 2026.

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