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Article

The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans.

PloS one - 1 Jan 2020

Naidoo Kewreshini K, Shangase Zesuliwe B, Rashid Tabassum, Ngubane Ayanda, Ismail Nasreen, Ndung'u Thumbi, Thobakgale Christina F

Abstract excerpt

The Duffy Antigen Receptor for Chemokines (DARC)-null trait, common among persons of African descent and associated with lower absolute neutrophil counts (ANCs), may be linked to increased risk to certain infections including HIV-1 but the underlying causes are poorly understood. We hypothesized that DARC-null-linked neutropenia may negatively impact neutrophil immunoregulatory modulation of other immune cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33211774
DOI: 10.1371/journal.pone.0242448
PMCID: PMC7676658

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