Article
Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis.
Nature communications - 17 Nov 2020
Liu Qian, Zaba Lisa C, Satpathy Ansuman T, Longmire Michelle, Zhang Wen, Li Kun, Granja Jeffrey, Guo Chuang, Lin Jun, Li Rui, Tolentino Karen, Kania Gabriela, Distler Oliver, Fiorentino David, Chung Lorinda, Qu Kun, Chang Howard Y
Abstract excerpt
Systemic sclerosis (SSc) is a disease at the intersection of autoimmunity and fibrosis. However, the epigenetic regulation and the contributions of diverse cell types to SSc remain unclear. Here we survey, using ATAC-seq, the active DNA regulatory elements of eight types of primary cells in normal skin from healthy controls, as well as clinically affected and unaffected skin from SSc patients. We find that...
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