Subclonal variant calling with multiple samples and prior knowledge.

Abstract excerpt

MOTIVATION: Targeted resequencing of cancer genes in large cohorts of patients is important to understand the biological and clinical consequences of mutations. Cancers are often clonally heterogeneous, and the detection of subclonal mutations is important from a diagnostic point of view, but presents strong statistical challenges. RESULTS: Here we present a novel statistical approach for calling mutations from...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Biometry
• Share to Genome, Human