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Article

Inhibition of ULK1 promotes the death of leukemia cell in an autophagy irrelevant manner and exerts the antileukemia effect

1 Jan 2021

Abstract excerpt

Because of disease relapse and drug resistance, patients with various subtypes of acute myeloid leukemia (AML) suffer low rate of 5-year survival. Although our understanding of the molecular pathogenesis of AML has made progress, there is a real need to develop new therapeutic targets and drugs to target leukemia for improving the treatment of patients with AML.1 As the homologous of autophagy-related 1 (ATG1),...

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PMID: 33463048
DOI: 10.1002/ctm2.282

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