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Article

Reactivating the ARF-p53 axis in AML cells by targeting ULF.

Cell cycle (Georgetown, Tex.) - 1 Aug 2010

Chen Delin, Yoon Jong-Bok, Gu Wei

Abstract excerpt

The tumor suppressor ARF plays an essential role in the cellular response to oncogenic stress mainly through activation of p53. Nucleophosmin (NPM), a multifunctional protein, forms a stable protein complex with ARF in the nucleolus and protects ARF from the proteasome-mediated degradation. Notably, NPM is mutated in about one third of acute myeloid leukaemia (AML) patients and these mutations lead to aberrant...

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Share to Gene Expression Regulation, Leukemic
Share to Leukemia, Myeloid, Acute
Share to Mutant Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nucleophosmin

Share to Protein Stability

Share to Tumor Suppressor Protein p14ARF

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Source

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Identifiers

PMID: 20699639
DOI: 10.4161/cc.9.15.12355
PMCID: PMC3040923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Reactivating the ARF-p53 axis in AML cells by targeting ULF.PMID 20699639Read ↗

Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.Semantic proximity Read ↗

Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor ProteinSemantic proximity Read ↗

The Myc-Nucleophosmin-ARF network: A complex web unveiledSemantic proximity Read ↗

Nucleophosmin 1 Mutations in Acute Myeloid Leukemia.Semantic proximity Read ↗

NPM1 mutant maintains ULK1 protein stability via TRAF6-dependent ubiquitination to promote autophagic cell survival in leukemia.Semantic proximity Read ↗

Post-Translational Regulation of ARF: Perspective in CancerSemantic proximity Read ↗

Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.Semantic proximity Read ↗

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.Semantic proximity Read ↗

FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemiaSemantic proximity Read ↗

The ARF tumor suppressor: Structure, functions and status in cancerSemantic proximity Read ↗

EAPB0503, an Imidazoquinoxaline Derivative Modulates SENP3/ARF Mediated SUMOylation, and Induces NPM1c Degradation in NPM1 Mutant AML.Semantic proximity Read ↗

Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3.Semantic proximity Read ↗

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