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Article

Optineurin enhances the chemoresistance by activating mitophagy in acute myeloid leukemia with NPM1 mutation.

Free radical biology & medicine - 1 May 2026

Tang Lisha, Wu Nan, Xiao Qiaoling, Yang Jing, Ren Jun, Chen Xinyi, Zhao Wen, Liu Yongcan, Hu Jiayuan, Yang Zailin, Gao Xiaoling, Zhang Ling

Abstract excerpt

Acute myeloid leukemia (AML) with nucleophosmin 1 (NPM1) mutation is a common genetic subtype with unique pathological features. However, current therapies remain challenged by relapse and drug resistance, underscoring an urgent need for novel therapeutic strategies. In this study, we identified hyperactivated mitophagy as a critical metabolic vulnerability in NPM1-mutated AML through bioinformatics analysis and...

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Share to Cytarabine
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Membrane Transport Proteins

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Share to Transcription Factor TFIIIA

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Source

Identifiers

PMID: 41722661
DOI: 10.1016/j.freeradbiomed.2026.02.049

Genes

NPM1
OPTN
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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