Article
Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis.
Nature genetics - 1 Jul 2023
Sampath Kumar Abhishek, Tian Luyi, Bolondi Adriano, Hernández Amèlia Aragonés, Stickels Robert, Kretzmer Helene, Murray Evan, Wittler Lars, Walther Maria, Barakat Gabriel, Haut Leah, Elkabetz Yechiel, Macosko Evan Z, Guignard Léo, Chen Fei, Meissner Alexander
Abstract excerpt
Spatiotemporal orchestration of gene expression is required for proper embryonic development. The use of single-cell technologies has begun to provide improved resolution of early regulatory dynamics, including detailed molecular definitions of most cell states during mouse embryogenesis. Here we used Slide-seq to build spatial transcriptomic maps of complete embryonic day (E) 8.5 and E9.0, and partial E9.5...
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