Multiple Sclerosis: Shall We Target CD33?

doi:10.3390/genes11111334

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Article

Multiple Sclerosis: Shall We Target CD33?

Genes - 12 Nov 2020

Siokas Vasileios, Tsouris Zisis, Aloizou Athina-Maria, Bakirtzis Christos, Liampas Ioannis, Koutsis Georgios, Anagnostouli Maria, Bogdanos Dimitrios P, Grigoriadis Nikolaos, Hadjigeorgiou Georgios M, Dardiotis Efthimios

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). Myeloid lineage cells (microglia and macrophages) may participate in the pathogenic mechanisms leading to MS. CD33 is a transmembrane receptor, mainly expressed by myeloid lineage cells. CD33 rs3865444 is a promoter variant previously associated with Alzheimer's disease, whose role in MS remains obscure. OBJECTIVE: To...

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PMID: 33198164
DOI: 10.3390/genes11111334
PMCID: PMC7696272

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