Distribution of IL-33 genetic variants and circulating IL-33 levels in patients with multiple sclerosis: associations with clinical parameters in a Lithuanian population study.

Abstract excerpt

Interleukin-33 (IL-33) is an important regulator of immune and neuroinflammatory responses implicated in multiple sclerosis (MS), yet its genetic contribution to disease susceptibility remains unclear. In this study, we examined three IL-33 variants (rs1157505, rs7044343, rs11792633) and circulating IL-33 levels in a Lithuanian case-control cohort (280 MS patients and 280 controls). No statistically significant...