Article
Quaternary Ammonium Compound Disinfectants Reduce Lupus-Associated Splenomegaly by Targeting Neutrophil Migration and T-Cell Fate.
Frontiers in immunology - 1 Jan 2020
Abdelhamid Leila, Cabana-Puig Xavier, Mu Qinghui, Moarefian Maryam, Swartwout Brianna, Eden Kristin, Das Prerna, Seguin Ryan P, Xu Libin, Lowen Sarah, Lavani Mital, Hrubec Terry C, Jones Caroline N, Luo Xin M
Abstract excerpt
Hypersensitivity reactions and immune dysregulation have been reported with the use of quaternary ammonium compound disinfectants (QACs). We hypothesized that QAC exposure would exacerbate autoimmunity associated with systemic lupus erythematosus (lupus). Surprisingly, however, we found that compared to QAC-free mice, ambient exposure of lupus-prone mice to QACs led to smaller spleens with no change in...
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