Article

Hemoglobin drives inflammation and initiates antigen spread and nephritis in lupus

2020-11-27

Abstract excerpt

Hemoglobin (Hb) has well-documented inflammatory effects and is normally efficiently scavenged; clearance mechanisms can be overwhelmed during conditions of erythrocyte lysis, a condition that may occur in systemic lupus erythematosus. Whether Hb is preferentially inflammatory in lupus and additionally induces autoreactivity against prominent autoantigens was assessed. Peripheral blood mononuclear cells derived fr...

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Literature Corpus work: 1d4557ec-5e22-53d6-bcd7-3ad32c4896d9
DOI: 10.1101/2020.11.27.399501

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