Article
Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity.
Frontiers in immunology - 1 Jan 2024
Raudszus Leonore, Bahreini Farbod, Allan Susanne, Kalies Kai-Uwe, Caldwell Charles C, Kalies Kathrin
Abstract excerpt
Neutrophils are rapidly recruited to sites of infection, injury, or to immune complexes. Upon arrival, they initiate degranulation, release reactive oxygen species (ROS), and/or nuclear extracellular traps (NETs) to eliminate invading microorganisms, clear debris, or remove abnormal immunoglobulins. While these processes ideally trigger healing and a return to balance, overshooting neutrophil function can lead to...
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