Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> TNFAIP3 encodes A20 that negatively regulates nuclear factor kappa light chain enhancer of activated B cells (NF-κB), the major transcription factor coordinating inflammatory gene expression. TNFAIP3 polymorphisms have been linked with a spectrum of inflammatory and autoimmune diseases and recently, loss-of-function mutations in A20 were found to cause a novel inflammatory...

Topics

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• Haploinsufficiency
• HEK293 Cells
• Hereditary Autoinflammatory Diseases
• I-kappa B Kinase
• Mutation
• Mutation, Missense
• NF-kappa B
• Tumor Necrosis Factor alpha-Induced Protein 3

Identifiers and source

Literature Corpus work

5761c9c8-ae9f-5f12-b853-c2c839e24d96

DOI

10.1101/401034