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Article

Mutations of α1F45 residue of GABAA receptor loop G reveal its involvement in agonist binding and channel opening/closing transitions.

Biochemical pharmacology - 1 Jul 2020

Brodzki Marek, Michałowski Michał A, Gos Michalina, Mozrzymas Jerzy W

Abstract excerpt

GABAA receptors (GABAARs) mediate inhibitory neurotransmission in the mammalian brain. Recently, numerous GABAAR static structures have been published, but the molecular mechanisms of receptor activation remain elusive. Loop G is a rigid β-strand belonging to an extensive β-sheet that spans the regions involved in GABA binding and the interdomain interface which is important in receptor gating. It has been...

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Identifiers

PMID: 32194055
DOI: 10.1016/j.bcp.2020.113917

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