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Article

GABAA receptor subunit M2-M3 linkers have asymmetric roles in pore gating and diazepam modulation.

Biophysical journal - 16 Jul 2024

Nors Joseph W, Endres Zachary, Goldschen-Ohm Marcel P

Abstract excerpt

GABAA receptors (GABAARs) are neurotransmitter-gated ion channels critical for inhibitory synaptic transmission as well as the molecular target for benzodiazepines (BZDs), one of the most widely prescribed class of psychotropic drugs today. Despite structural insight into the conformations underlying functional channel states, the detailed molecular interactions involved in conformational transitions and the...

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Identifiers

PMID: 38400541
DOI: 10.1016/j.bpj.2024.02.016
PMCID: PMC11309982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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