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Article

The role of heterogeneity of intersubunit interfaces in the outer membrane leaflet in maintaining GABAA receptor activity.

European biophysics journal : EBJ - 1 Feb 2026

Rossokhin Alexey

Abstract excerpt

GABA type A receptors (GABAAR) mediate fast inhibition processes in the CNS. We proposed that β2 Arg269 (19′) residue maintains the activated state of GABAAR by wedging its bulky side chain into β(+)/α(–) transmembrane interfaces in the outer membrane leaflet. To explore this hypothesis, we used the cryo-EM structure (6X3Z) of agonist-bound α1β2γ2 GABAAR and molecular dynamics. We found that the Arg19′ side chain...

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PMID: 41636797
DOI: 10.1007/s00249-026-01816-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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