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Performance and considerations in the use of diagnostic mutation panels for clonality testing in non-small-cell lung carcinoma

1 May 2025

Abstract excerpt

INTRODUCTION: Next-generation sequencing (NGS) mutation panels are widely implemented and commonly applied to aid clonality classification for non-small-cell lung carcinoma (NSCLC) patients with multiple tumors. Performance of different NGS panels for clonality classification, however, remains unresolved. METHODS: We assembled 210 primary and metastatic pairs from lung adenocarcinoma (LUAD) and lung squamous-cell...

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PMID: 40373350
DOI: 10.1016/j.esmoop.2025.105072

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