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Article

Heterogeneity of Metabolic Vulnerability in Imatinib -Resistant Gastrointestinal Stromal Tumor.

Cells - 26 May 2020

Huang Wen-Kuan, Gao Jiwei, Chen Ziqing, Shi Hao, Yuan Juan, Cui Huanhuan L, Yeh Chun-Nan, Bränström Robert, Larsson Catharina, Li Shuijie, Lui Weng-Onn

Abstract excerpt

Metabolic reprogramming is a hallmark of cancer cells in response to targeted therapy. Decreased glycolytic activity with enhanced mitochondrial respiration secondary to imatinib has been shown in imatinib-sensitive gastrointestional stromal tumors (GIST). However, the role of energy metabolism in imatinib-resistant GIST remains poorly characterized. Here, we investigated the effect of imatinib treatment on...

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Identifiers

PMID: 32466502
DOI: 10.3390/cells9061333
PMCID: PMC7348861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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