Article
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer.
JNCI cancer spectrum - 1 Apr 2021
Dahlgren Malin, George Anthony M, Brueffer Christian, Gladchuk Sergii, Chen Yilun, Vallon-Christersson Johan, Hegardt Cecilia, Häkkinen Jari, Rydén Lisa, Malmberg Martin, Larsson Christer, Gruvberger-Saal Sofia K, Ehinger Anna, Loman Niklas, Borg Åke, Saal Lao H
Abstract excerpt
Background: More than three-quarters of primary breast cancers are positive for estrogen receptor alpha (ER; encoded by the gene ESR1), the most important factor for directing anti-estrogenic endocrine therapy (ET). Recently, mutations in ESR1 were identified as acquired mechanisms of resistance to ET, found in 12% to 55% of metastatic breast cancers treated previously with ET. Methods: We analyzed 3217...
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