Article
Comparing pooled peptides with intact protein for accessing cross-presentation pathways for protective CD8+ and CD4+ T cells.
The Journal of biological chemistry - 3 Apr 2009
Zhang Hongwei, Hong Hai, Li Demin, Ma Shiwu, Di Ying, Stoten Adam, Haig Neil, Di Gleria Katalin, Yu Zhanru, Xu Xiao-Ning, McMichael Andrew, Jiang Shisong
Abstract excerpt
To better understand the mechanisms of intracellular trafficking and presentation of exogenous peptides by antigen-presenting cells (APC), we compared the handling of overlapping 24-mer peptides from HIV Nef either mixed or covalently linked in tandem in one protein. Once internalized, peptides trafficked not only to endosomes but also to cytosol, and activated CD8(+) and CD4(+) T cells. In contrast, whole...
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