Article
Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy.
Journal of translational medicine - 31 Mar 2011
Ma Wenxue, Smith Trevor, Bogin Vladimir, Zhang Yu, Ozkan Cengiz, Ozkan Mihri, Hayden Melanie, Schroter Stephanie, Carrier Ewa, Messmer Davorka, Kumar Vipin, Minev Boris
Abstract excerpt
BACKGROUND: Many peptide-based cancer vaccines have been tested in clinical trials with a limited success, mostly due to difficulties associated with peptide stability and delivery, resulting in inefficient antigen presentation. Therefore, the development of suitable and efficient vaccine carrier systems remains a major challenge. METHODS: To address this issue, we have engineered polylactic-co-glycolic acid...
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