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Article

Multistep mechanism of substrate binding determines chaperone activity of Hsp70.

Nature structural biology - 1 Jul 2000

Mayer M P, Schröder H, Rüdiger S, Paal K, Laufen T, Bukau B

Abstract excerpt

The 70 kDa heat shock proteins (the Hsp70 family) assist refolding of their substrates through ATP-controlled binding. We have analyzed mutants of DnaK, an Hsp70 homolog, altered in key residues of its substrate binding domain. Substrate binding occurs by a dynamic mechanism involving: a hydropho...

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Identifiers

PMID: 10876246
DOI: 10.1038/76819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10876246-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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