Article
Detection of ERG11 Overexpression in Candida albicans isolates from environmental sources and clinical isolates treated with inhibitory and subinhibitory concentrations of fluconazole.
Mycoses - 1 Feb 2021
Morais Vasconcelos Oliveira Josimary, Conceição Oliver Josidel, Latércia Tranches Dias Amanda, Barbosa Padovan Ana Carolina, Siqueira Caixeta Ester, Caixeta Franco Ariosa Marília
Abstract excerpt
BACKGROUND: Candida species can cause serious infection in patients with changes in defence mechanisms and/or when anatomical barriers are compromised. Mutations and overexpression in the ERG11 gene are described as molecular mechanisms of azole resistance. Information is limited on these mechanisms in the presence of subinhibitory concentrations of fluconazole. OBJECTIVES: This study aimed to evaluate the...
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