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Article

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates.

BMC infectious diseases - 10 Apr 2018

Jin Longyang, Cao Zhuorui, Wang Qi, Wang Yichen, Wang Xiaojuan, Chen Hongbin, Wang Hui

Abstract excerpt

BACKGROUND: Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated. METHODS: Twenty-two C. tropicalis clinical isolates, including 12 fluconazole-resistant isolates and 10 fluconazole-susceptible isolates, were collected from a tertiary care teaching hospital in Beijing between 2013 and...

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Identifiers

PMID: 29631565
DOI: 10.1186/s12879-018-3082-0
PMCID: PMC5891969

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