Profiling of 149 Salivary Duct Carcinomas, Carcinoma Ex Pleomorphic Adenomas, and Adenocarcinomas, Not Otherwise Specified Reveals Actionable Genomic Alterations.

doi:10.1158/1078-0432.CCR-15-2568

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Article

Profiling of 149 Salivary Duct Carcinomas, Carcinoma Ex Pleomorphic Adenomas, and Adenocarcinomas, Not Otherwise Specified Reveals Actionable Genomic Alterations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2016

Wang Kai, Russell Jeffery S, McDermott Jessica D, Elvin Julia A, Khaira Depinder, Johnson Adrienne, Jennings Timothy A, Ali Siraj M, Murray Molly, Marshall Carrie, Oldham Dwight S, Washburn Donna, Wong Stuart J, Chmielecki Juliann, Yelensky Roman, Lipson Doron, Miller Vincent A, Stephens Philip J, Serracino Hilary S, Ross Jeffrey S, Bowles Daniel W

Abstract excerpt

PURPOSE: We sought to identify genomic alterations (GA) in salivary gland adenocarcinomas, not otherwise specified (NOS), salivary duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca ex PA), and salivary carcinoma, NOS. EXPERIMENTAL DESIGN: DNA was extracted from 149 tumors. Comprehensive genomic profiling (CGP) was performed on hybridization-captured adaptor ligation-based libraries of 182 or 315...

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PMID: 27334835
DOI: 10.1158/1078-0432.CCR-15-2568

Genes

RET
CCDC6
ERBB2
NCOA4
NOTCH1

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