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Article

The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion.

International journal of molecular sciences - 23 Jan 2024

Ziehe Dominik, Marko Britta, Thon Patrick, Rahmel Tim, Palmowski Lars, Nowak Hartmuth, von Busch Alexander, Wolf Alexander, Witowski Andrea, Vonheder Jolene, Ellger Björn, Wappler Frank, Schwier Elke, Henzler Dietrich, Köhler Thomas, Zarbock Alexander, Ehrentraut Stefan Felix, Putensen Christian, Frey Ulrich Hermann, Anft Moritz, Babel Nina, Adamzik Michael, Koos Björn, Bergmann Lars, Unterberg Matthias, Rump Katharina

Abstract excerpt

Sepsis is a common life-threatening disease caused by dysregulated immune response and metabolic acidosis which lead to organ failure. An abnormal expression of aquaporins plays an important role in organ failure. Additionally, genetic variants in aquaporins impact on the outcome in sepsis. Thus, we investigated the polymorphism (rs17553719) and expression of aquaporin-3 (AQP3) and correlated these measurements...

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Identifiers

PMID: 38338680
DOI: 10.3390/ijms25031400
PMCID: PMC10855683

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