Article
Investigation of T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) polymorphisms in essential thrombocythaemia (ET).
Hematology (Amsterdam, Netherlands) - 1 Jul 2017
Han Fuyan, Wang Guanghai, Li Yuantang, Tian Wenjun, Dong Zhenfang, Cheng Shiqing, Liu Yiqing, Qu Teng, Wang Xiaoying, Wang Yong, Zhang Bingchang, Ju Ying
Abstract excerpt
OBJECTIVES: T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) is preferentially expressed on terminally differentiated Th1 cells and inhibits their IFN-γ production. It has been reported that chronic inflammation may be an important driving force for myeloproliferative neoplasms (MPNs). Therefore, we hypothesized that as an important inflammation regulator, TIM-3 may be involved in essential...
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