Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still's disease.

doi:10.1186/s13075-017-1406-x

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Article

Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still's disease.

Arthritis research & therapy - 12 Sept 2017

Asano Tomoyuki, Furukawa Hiroshi, Sato Shuzo, Yashiro Makiko, Kobayashi Hiroko, Watanabe Hiroshi, Suzuki Eiji, Ito Tomoyuki, Ubara Yoshifumi, Kobayashi Daisuke, Iwanaga Nozomi, Izumi Yasumori, Fujikawa Keita, Yamasaki Satoshi, Nakamura Tadashi, Koga Tomohiro, Shimizu Toshimasa, Umeda Masataka, Nonaka Fumiaki, Yasunami Michio, Ueki Yukitaka, Eguchi Katsumi, Tsuchiya Naoyuki, Tohma Shigeto, Yoshiura Koh-Ichiro, Ohira Hiromasa, Kawakami Atsushi, Migita Kiyoshi

Abstract excerpt

BACKGROUND: HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical features of adult onset Still's disease (AOSD) in a Japanese population by determining the DRB1 allele distributions. METHODS: DRB1 genotyping of 96 patients with AOSD and 1,026 healthy controls was performed. Genomic DNA...

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PMID: 28899403
DOI: 10.1186/s13075-017-1406-x
PMCID: PMC5596459

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