Role of Ten eleven translocation‐2 (Tet2) in modulating neuronal morphology and cognition in a mouse model of Alzheimer's disease

Abstract excerpt

Abstract Abnormal expression of Ten eleven translocation‐2 (Tet2) contributes to the pathogenesis of Alzheimer's disease (AD). However, to date, the role of Tet2 in modulating neuronal morphology upon amyloid‐β (Aβ)‐induced neurotoxicity has not been shown in a mouse model of AD. Here, we have developed a model of injured mouse hippocampal neurons induced by Aβ42oligomers in vitro. We also investigated the role...

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